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Home - Products - GPCR/G Protein - Antibacterial - Metallo β-lactamase ligand 1

Metallo β-lactamase ligand 1

CAS No. 1087784-71-1

Metallo β-lactamase ligand 1( —— )

Catalog No. M28184 CAS No. 1087784-71-1

Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Metallo β-lactamase ligand 1
  • Note
    Research use only, not for human use.
  • Brief Description
    Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.
  • Description
    Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.(In Vitro):The toxicity of Metallo β-lactamase ligand 1 is extremely low in HeLa cells.(In Vivo):Administration of Metallo β-lactamase ligand 1 significantly improves the survival rate in mice infected with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced).
  • In Vitro
    One effective measure against β-lactam antibacterial resistant bacteria is to use an inhibitor of β-lactamase, the enzyme responsible for its resistance mechanism, together with an appropriate β-lactam antibacterial agent. The toxicity of Metallo-beta-lactamase ligand 1 (Compound A) is extremely low in HeLa cells.
  • In Vivo
    After infecting mice with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced), Metallo-beta-lactamase ligand 1 (compound A; 100 mg/kg; intraperitoneal injection) is administered, and life and death are observed. Administration of Metallo-beta-lactamase ligand 1 (compound A) significantly improves the survival rate.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    IL-1β| IL-10
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1087784-71-1
  • Formula Weight
    219.21
  • Molecular Formula
    C7H9NO5S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (1140.41 mM)
  • SMILES
    Cc1oc(C)c(c1C(O)=O)S(N)(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Badria FA, Ameen M, Akl MR. Evaluation of cytotoxic compounds from calligonum comosum L. growing in Egypt. Z Naturforsch C J Biosci. 2007 Sep-Oct;62(9-10):656-60.
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